Corpus callosum atrophy and neuropsychological outcome following carbon monoxide poisoning.
نویسندگان
چکیده
This study assessed the effects of carbon monoxide (CO) poisoning on the corpus callosum (CC). Sixty-two CO-poisoned patients had MRI scans and a battery of neuropsychological tests within 24 h (day of exposure) of CO poisoning and at 6 months post CO exposure. Serial quantitative magnetic resonance imaging (QMRI) analysis of the CC was carried out, with the day of exposure scans compared to the 6-month scans. There was no difference between normal subjects' CC and the baseline scans in the CO-poisoned patients. We detected a 15-mm2 loss in the cross-sectional surface area of the CC between baseline and the 6-month follow-up scans. The effect on the CC was generalized atrophy rather than CC subregion-specific changes. Neuropsychological test results performed at baseline and at 6 months did not correlate with the level of CC atrophy. Independent of any CC effects, the patients exhibited impaired memory, attention, and executive functioning on baseline testing, with variable improvement in cognitive function at 6 months. Quantitative MRI analysis allows for the detection of subtle CC changes that may not otherwise be observed following CO poisoning. The long-term effects of CO on the brain have been historically underestimated; however, we found subtle but significant CC atrophy and cognitive impairments following CO poisoning.
منابع مشابه
Continuing decline of memory skills with significant recovery of intellectual function following severe carbon monoxide exposure: clinical, psychometric, and neuroimaging findings.
Extensive clinical, psychometric, and neuroimaging data are presented and interpreted with regard to a 35-year-old, White male college graduate who was exposed to severe carbon monoxide (CO) poisoning. The patient was comatose for 21 days following the exposure. Several other people, who were in the same room as the patient, died due to the toxic effects of the CO. The patient was employed prem...
متن کاملNeuropsychological outcome after carbon monoxide exposure following a storm: a case-control study
BACKGROUND The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of France (January 2009) in a homogeneous group of patients compared to a group ...
متن کاملCorrelation of computed tomography, magnetic resonance imaging and clinical outcome in acute carbon monoxide poisoning.
BACKGROUND AND OBJECTIVES Carbon monoxide is a toxic gas for humans and is still a silent killer in both developed and developing countries. The aim of this case series was to evaluate early radiological images as a predictor of subsequent neuropsychological sequelae, following carbon monoxide poisoning. CASE 1 After carbon monoxide exposure, early computed tomography scans and magnetic reson...
متن کاملNeuropsychological impairment from acute low-level exposure to carbon monoxide.
OBJECTIVE To investigate the effects of acute low-level exposure to carbon monoxide on higher cognitive functions in healthy humans. DESIGN An empirical study of the effects of low-level exposure to carbon monoxide on higher cognitive functions in young healthy volunteers and a matched nonexposed control group. SETTING A dormitory at the Hebrew University campus in Jerusalem, Israel. PART...
متن کاملRisk factors for the delayed onset of neuropsychologic sequelae following carbon monoxide poisoning
AIM Carbon monoxide (CO) poisoning often manifests delayed neuropsychological sequelae. The risks and preventive factors for the development of delayed neuropsychological sequelae are controversial at present. The purpose of this retrospective study was to assess the risk factors for this condition. METHOD We studied 81 patients with CO poisoning admitted to the Critical Care and Emergency Me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
دوره 17 2 شماره
صفحات -
تاریخ انتشار 2002